Partnership in Research and Development
For over 30 years Cyto Labor has been working with high-affinity polymers and their use in immuno enzymatic measurement techniques. The material Cytex, developed by us, can be used as granules, as powders as well as in any form produced by injection molding. The matrix we currently use most often has the format of flat microtiter plates.
Cytex has the ability to bind biomolecules (proteins, lipids, carbohydrates, nucleic acids as well as a large number of other organic and inorganic substances) with high affinity. This hydrophobic bond exceeds the affinity, stability, and capacity of conventional matrices, such as those of polystyrene or nitrocellulose many times over.
By suitable buffer systems, the binding ability can be specifically controlled. Thus, templates (substances to be investigated) can be bound, but detection media (eg enzyme-labeled antibodies or fluorescent DNA samples) are not bound. This opens up a variety of possible applications for analytical procedures for biomedical or clinical diagnostics or measuring methods for biology and environmental technology.
Preparative methods can be used for the isolation and purification of biomolecules. As a relatively small company, we have limited ability to fully exploit the potential of our developments. We therefore offer our know-how and our many years of experience to partners from industry and science.
A possible cooperation includes the following areas:
Cytex’s ability to hydrophobically bind high-affinity biomolecules provides a foundation for applications in basic biomedical research as well as in medical diagnostics.
So far, immunoassays for neuropeptides such as vasopressin, oxytocin and corticotropin releasing hormones (CRH) have been developed as antigen capture assays.
For the screening of serum samples, an antibody-capture assay is used.
Both methods allow the production and execution of highly sensitive and enormously inexpensive tests – as an alternative to conventional systems with microtiter plates.
Complicated washing machines, expensive pipetting machines and evaluation units are dispensable.
Fine granulates up to powders with a particle size in the micrometer range are excellently suited as column material for the purification of peptides, proteins or nucleic acids.
Antibody-loaded Cytex particles can be used as a column material in conjunction with suitable buffer systems for the quantitative isolation of proteins, e.g. As culture supernatants, serum, urine or saliva can be used.
Past cooperations with industrial partners
Pulsamed GmbH, Simmern
Omicron GmbH Jena
Neuroscience Inc. Osceola WI, USA
Pharmasan Inc. Osceola WI, USA
With Academic Institutions
Institut für Anatomie und Zellbiologie, Universität Ulm
Dept. of Biochemistry
Max-Planck-Institut für Psychiatrie, Arbeitsgruppe Molekulare Neuroendokrinokogie
Institut für Anatomie II, Friedrich-Schiller-Universität Jena
Scripps Research Foundation, La Jolla, CA, USA
Cyto Labor GmbH is a small-sized company and is available as an industrial partner for applications by academic institutions.