Cytolisa IgG4 test, 22 foods
22 foods are tested for IgG4. This test is particularly recommended for non-specific allergic reactions or chronic diseases such as coeliac disease or autoimmune pancreatitis in order to relieve the immune system by changing the diet.
IgG4 is a relatively short-lived subclass of IgG. This immunoglobulin is part of a specific immune response to an allergen and leads to the release of histamine from mast cells and basophilic granulocytes, resulting in the development of acute type I allergy symptoms. This can range from itching and inflammation to shock. Chronic diseases such as coeliac disease or autoimmune pancreatitis are also associated with this immunoglobulin. Since the biological half-life of IgG4 in the blood is somewhat longer than that of IgE, the measurement of IgG4 is a valuable parameter in certain allergic diseases. As with any immunosorbent assay, IgG4 diagnostics are only of diagnostic value in conjunction with the patient’s medical history and acute findings. For example, beekeepers who are regularly stung by bees have high IgG4 titres against bee venom but no allergic reaction.
Further reading:
Bruijnzeel-Koomen, C., et al, Adverse reactions to food*. Allergy, 1995. 50(8): p. 623-635.
Schuurman, J., et al, Complementation of Der P 2-induced histamine release from human basophils sensitized with monoclonal IgE: not only by IgE, but also by IgG antibodies directed to a nonoverlapping epitope of Der p 2. J Allergy Clin Immunol, 1998. 101(3): p. 404-9.
Villalta, D., et al, IgG antibodies against deamidated gliadin peptides for diagnosis of celiac disease in patients with IgA deficiency. Clin Chem, 2010. 56(3): p. 464-8.
van Neerven, R.J., et al, IgE-mediated allergen presentation and blocking antibodies: regulation of T-cell activation in allergy. Int Arch Allergy Immunol, 2006. 141(2): p. 119-29.
Stone, J.H., Y. Zen, and V. Deshpande, IgG4-Related Disease. New England Journal of Medicine, 2012. 366(6): p. 539-551.
Garcia-Robaina, J.C., et al, The natural history of Apis-specific IgG and IgG4 in beekeepers. Clin Exp Allergy, 1997. 27(4): p. 418-23.
Price:
59,30 Euro incl. VAT
The following foods are tested:
Apple
Avocado
Banana
Peanut
Shrimp
Barley
Hazelnut
Hen’s egg
Cod
Carrot
Potato
Kiwi
Cow’s milk
Salmon
Orange
Beef
Rye
Celery root
Soybean
Tomato
Wheat
Lemon